Publications

(* corresponding author; # equal contribution)

32. Fei Wang#, Xinye Wang#, Xuehao Zhang, Mengying Hu*. Immune activation and regulation mediated by immune cell-derived EVs (iEVs). Essays in Biochemistry (2025): p.EBC20253005.

Prior to OSU:

31. Mengying Hu, Linda Bojmar, Candia M Kenific, Inbal Wortzel, Gang Wang, Guojie Zhong, Serena Lucotti, Simone Caielli, Zurong Wan, Sarah Qureshy, Richard Piszczatowski, Purnima Ravisankar, Huajuan Wang, Pernille Lauritzen, Henrik Molina, Jack Bui, Nancy Boudreau, Ben Z. Stanger, Yael Aylon, Moshe Oren, Jacqueline Bromberg, David Kelsen, Laura Santambrogio, Melody Y. Zeng, Virginia Pascual, William R. Jarnagin, Irina R. Matei*, Haiying Zhang*, David Lyden*. Activated T cell extracellular vesicle DNA transfer enhances antigen presentation and anti-tumor immunity. (Under revision, Cancer Cell)

30. Mengying Hu#, Candia Kenific#, Nancy Boudreau, David Lyden*. Tumor-derived nanoseeds condition the soil for metastatic organotropism. Seminar in Cancer Biology 93 (2023): 70-82.

29. Mengying Hu, Leaf Huang. Strategies targeting tumor immune and stromal microenvironment and their clinical relevance. Advanced Drug Delivery Reviews (2022): 114137.

28. Mengying Hu, Ying Wang, Zhengsheng Liu, Zhuo Yu, Kaiyun Guan, Mengrui Liu, Menglin Wang, Jun Tan, Leaf Huang*. Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis. Nature Nanotechnology 16.4 (2021): 466-477. DOI: 10.1038/s41565-020-00836-6.

News & Views in Nature Nanotechnology: https://www.nature.com/articles/s41565-020-00832-w

News in BioWorld: https://www.bioworld.com/articles/502995-macrophages-key-to-liver-cells-relaxin

Recommended in Faculty Opinions: https://facultyopinions.com/prime/739434154

27. Mengying Hu, Xuefei Zhou, Ying Wang, Kaiyun Guan, Leaf Huang*. Relaxin-FOLFOX-IL-12 triple combination therapy engages memory response and achieves long-term survival in colorectal cancer liver metastasis. Journal of Controlled Release 319 (2020): 213-221.

26. Huan Xu#, Mengying Hu#, Mengrui Liu, Sai An, Kaiyun Guan, Menglin Wang, Lei Li, Jing Zhang, Jun Li, Leaf Huang*. Nano-puerarin regulates tumor microenvironment and facilitates chemo-and immunotherapy in murine triple negative breast cancer model. Biomaterials 235 (2020): 119769.

25. Mengying Hu, Ying Wang, Ligeng Xu, Sai An, Yu Tang, Xuefei Zhou, Jingjing Li, Rihe Liu, Leaf Huang*. Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy. Nature Communications 10.1 (2019): 2993. (Featured article in Colorectal Cancer Awareness Month & Liver Cancer Awareness Month Collections of Nature Communications)

Recommended in Faculty Opinions: https://facultyopinions.com/prime/736141936

24. Mengying Hu, Leaf Huang*. Nanomaterial Manipulation of Immune Microenvironment in the Diseased Liver. Advanced Functional Materials 29.7 (2019): 1805760.

23. Mengying Hu, Yurun Shen, Lu Zhang, Liyan Qiu*. Polymersomes via self-assembly of amphiphilic β-cyclodextrin-centered triarm star polymers for enhanced oral bioavailability of water-soluble chemotherapeutics. Biomacromolecules 17.3 (2016): 1026-1039.

22. Mengying Hu, Jinfang Zhu, Liyan Qiu*. Polymer micelle-based combination therapy of paclitaxel and resveratrol with enhanced and selective antitumor activity. RSC Advances 4.109 (2014): 64151-64161.

21. Ying Wang, Sirui Li, Mengying Hu, Yuchen Yang, Ellie McCabe, Lillian Zhang, Andrew M. Withrow, Jenny P.-Y. Ting, Rihe Liu*. Universal STING mimic boosts antitumour immunity via preferential activation of tumour control signalling pathways.” Nature Nanotechnology (2024): 1-11.

20. Gang Wang, Jianlong Li, Linda Bojmar, Haiyan Chen, Zhong Li, Gabriel C. Tobias, Mengying Hu, Edwin A. Homan, Serena Lucotti, Fengbo Zhao, Valentina Posada, Peter R. Oxley, Michele Cioffi, Han Sang Kim, Huajuan Wang, Pernille Lauritzen, Nancy Boudreau, Zhanjun Shi, Christin E. Burd, Jonathan H. Zippin, James C. Lo, Geoffrey S. Pitt, Jonathan Hernandez, Constantinos P. Zambirinis, Michael A. Hollingsworth, Paul M. Grandgenett, Maneesh Jain, Surinder K. Batra, Dominick J. DiMaio, Jean L. Grem, Kelsey A. Klute, Tanta M. Trippett, Mikala Egeblad, Doru Paul, Jacqueline Bromberg, David Kelsen, Vinagolu K. Rajasekhar, John H. Healey, Irina R. Matei, William R. Jarnagin, Robert E. Schwartz, Haiying Zhang, David Lyden*. Tumour extracellular vesicles and particles induce liver metabolic dysfunction. Nature 618(2023):374-382.

19. Zhongchi Li, Vivien Low, Valbona Luga, Janet Sun, Ethan Earlie, Bobak Parang, Kripa Shobana Ganesh, Sungyun Cho, Jennifer Endress, Tanya Schild, Mengying Hu, David Lyden, Wenbing Jin, Chunjun Guo, Noah Dephoure, Lewis C Cantley, Ashley M Laughney, John Blenis*. Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression. Nature Communications 13.1 (2022): 6239.

18. Xiaoyu Liu, Jingying Zhou, Haoran Wu, Shufen Chen, Lingyun Zhang, Wenshu Tang, Liang Duan, Ying Wang, Eleanor McCabe, Mengying Hu, Zhuo Yu, Hanzhuang Liu, Chung Huang Jonathan Choi, Joseph Jao-yiu Sung, Leaf Huang, Rihe Liu, Alfred Sze-lok Cheng*. Fibrotic immune microenvironment remodeling mediates superior anti-tumor efficacy of a nano-PD-L1 trap in hepatocellular carcinoma. Molecular Therapy (2022).

17. Sendi, Hossein, Mostafa Yazdimamaghani, Mengying Hu, Nikhila Sultanpuram, Jie Wang, Amber S. Moody, Ellie McCabe, Jiajie Zhang, Amanda Graboski, Liantao Li, Juan D Rojas, Paul A Dayton, Leaf Huang, Andrew Z Wang*. Nanoparticle delivery of miR-122 inhibits colorectal cancer liver metastasis. Cancer Research 82.1 (2021): 105-113.

16. Wang, Ying, Karthik Tiruthani, Sirui Li, Mengying Hu, Guojie Zhong, Yu Tang, Sourav Roy, Lillian Zhang, Jun Tan, Chengheng Liao, Rihe Liu*. mRNA Delivery of a Bispecific Single‐Domain Antibody to Polarize Tumor‐Associated Macrophages and Synergize Immunotherapy against Liver Malignancies. Advanced Materials 33 (2021): 2007603.

15. Xuefei Zhou, Yun Liu, Mengying Hu, Menglin Wang, Xiangrui Liu, Leaf Huang*. Relaxin gene delivery modulates macrophages to resolve cancer fibrosis and synergizes with immune checkpoint blockade therapy. Science Advances 7.8 (2021): eabb6596.

14. Nasha Qiu, Yun Liu, Qi Liu, Yanzuo Chen, Limei Shen, Mengying Hu, Xuefei Zhou, Youqing Shen, Jianqing Gao, Leaf Huang*. Celastrol nanoemulsion induces immunogenicity and downregulates PD-L1 to boost abscopal effect in melanoma therapy. Biomaterials 269 (2021): 120604.

13. Zhuo Yu, Jianfeng Guo, Mengying Hu, Yueqiu Gao, Leaf Huang*. Icaritin exacerbates mitophagy and synergizes with doxorubicin to induce immunogenic cell death in hepatocellular carcinoma. ACS nano 14.4 (2020): 4816-4828.

12. Yang Xiong, Wantong Song, Limei Shen, Ying Wang, Jing Zhang, Mengying Hu, Yun Liu, Jingjing Li, Sara Musetti, Rihe Liu, Leaf Huang*. Oral Metformin and Polymetformin Reprogram Immunosuppressive Microenvironment and Boost Immune Checkpoint Inhibitor Therapy in Colorectal Cancer. Advanced Therapeutics 3.12 (2020): 2000168

11. Sai An, Karthik Tiruthani, Ying Wang, Ligeng Xu, Mengying Hu, Jingjing Li, Wantong Song, Hongnan Jiang, JiruiSun, Rihe Liu, Leaf Huang*. Locally Trapping the C‐C Chemokine Receptor Type 7 by Gene Delivery Nanoparticle Inhibits Lymphatic Metastasis Prior to Tumor Resection. Small 15.9 (2019): 1805182.

10. Yanzuo Chen, Wantong Song, Limei Shen, Nasha Qiu, Mengying Hu, Yun Liu, Qi Liu, Leaf Huang*. Vasodilator Hydralazine Promotes Nanoparticle Penetration in Advanced Desmoplastic Tumor. ACS nano 13.2 (2019): 1751-1763.

9. Wantong Song, Karthik Tiruthani, Ying Wang, Limei Shen, Mengying Hu, Oleksandra Dorosheva, Kunyu Qiu, Karina A Kinghorn, Rihe Liu, Leaf Huang*. Trapping of Lipopolysaccharide to Promote Immunotherapy against Colorectal Cancer and Attenuate Liver Metastasis. Advanced Materials 30.52 (2018): 1805007.

8. Ying Wang, Wantong Song, Mengying Hu, Sai An, Ligeng Xu, Jingjing Li, Karina A Kinghorn, Rihe Liu, Leaf Huang*. Nanoparticle‐mediated HMGA1 Silencing Promotes Lymphocyte Infiltration and Boosts Checkpoint Blockade Immunotherapy for Cancer. Advanced Functional Materials 28.36 (2018): 1802847.

7. Hanyong Sun, Weiqin Yang, Yuan Tian, Xuezhen Zeng, Jingying Zhou, Myth TS Mok, Wenshu Tang, Yu Feng, Liangliang Xu, Anthony WH Chan, Joanna H Tong, Yue-Sun Cheung, Paul BS Lai, Hector KS Wang, Shun-Wa Tsang, King-Lau Chow, Mengying Hu, Rihe Liu, Leaf Huang, Bing Yang, Pengyuan Yang, Ka-Fai To, Joseph JY Sung, Grace LH Wong, Vincent WS Wong, Alfred SL Cheng*. An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma. Nature communications 9.1 (2018): 1-16.

6. Tyler J Goodwin, Limei Shen, Mengying Hu, Jingjing Li, Richard Feng, Oleksandra Dorosheva, Rihe Liu, Leaf Huang*. Liver specific gene immunotherapies resolve immune suppressive ectopic lymphoid structures of liver metastases and prolong survival. Biomaterials 141 (2017): 260-271.

5. Juan Li, Yang Du, Zhenqi Jiang, Yuchen Tian, Nianxiang Qiu, Yinjie Wang, Mengying Hu, Ruifen Zou, Lijia Luo, Shiyu Du, Jie Tian, Aiguo Wu*. Y1 receptor ligand-based nanomicelle as a novel nanoprobe for glioma-targeted imaging and therapy. Nanoscale 10.13 (2018): 5845-5851.

4. Jinfang Zhu, Mengying Hu, Liyan Qiu*. Drug resistance reversal by combretastatin-A4 phosphate loaded with doxorubicin in polymersomes independent of angiogenesis effect. Journal of Pharmacy and Pharmacology 69.7 (2017): 844-855.

3. Yurun Shen, Mengying Hu, Liyan Qiu*. Sequentially dual-targeting vector with nano-in-micro structure for improved docetaxel oral delivery in vivo. Nanomedicine 12.23 (2016): 3071-3086.

2. Jinfang Zhu, Xiaoping Xu, Mengying Hu, Liyan Qiu*. Co-encapsulation of combretastatin-A4 phosphate and doxorubicin in polymersomes for synergistic therapy of nasopharyngeal epidermal carcinoma. Journal of Biomedical Nanotechnology 11.6 (2015): 997-1006.

1. Qian Tang, Aiping Tu, Zhenzhen Deng, Mengying Hu, Weihui Zhong*. Progress in enantioselective phosphine organocatalysis. Chinese Journal of Chemistry 33.5 (2013): 954-970.